I don't preclude the possibilities of ultimate meanings & destinies put forth via metaphysical concepts, religions & spirituality, and that sort of thing.
But personally, I think it's important to take life as it comes and to form your own basis for right, wrong, meaning, everything. I feel like even if there is an ultimate, universal meaning to life that we have no way of knowing it anymore than we do anything else that extends beyond the spheres of reality that we can directly influence.
On top of that, I feel like most of the time it is actually important to not assign "meaning" to things in life, events or occurrences or anything, because this is arbitrarily limiting your own field of experience and setting yourself up for a depression when the reality around you is not checking off the items on your list.
If you feel strongly about something, or the lack of it, then yes I think you should pursue a course of action that will bring your reality closer to being inline with what you imagine as ideal. But if you are feeling very vague or unsure, I think that is the worst possible time to be chasing invisible carrots on sticks.
In my opinion, times of uncertainty and doubt are excellent opportunities to take stock of yourself and see how you measure up to your own standards, and discerning what exactly it is you want from your realty and the people or situations around you. It is not a time to do internal inventory checks and determine that you are not meeting some goal or ideal, but rather it is a chance for quiet introspection and a reevaluation of whatever it is that happened to make you question things in the first place.
You don't look inward for answers--you look inward for paths or courses through your existence.
You will (hopefully) never arrive at a concrete meaning for your life and a 12 step guideline to get to a preconceived destination, but with time you will figure out a course you can take through your own near future that will lead you away from your current state.
That's the other thing--realize that negative moments, moments of doubt, crisis of conscience, the times when you question, the "down" and "bad" times, all of these will pass with time because we are always moving, even when we don't realize it. Keep this in mind and do what you can to cherish even the bad times when shit is raining down on you, because these moments contribute to your development as much as anything else, and your hand is the strongest in shaping your existence.