Visually, its the same interface. There will still be four player support like the last game, (Guitar, Bass, Drums, Vocals) so dont expect anything changed with what worked so well the first time. The guitar controllers still have the same size and feel, but have been changed visually. Now, they sport a wooden finish to them to make it look more like acoustic guitars. This isnt a major change, but some players will appreciate the new look.
Overall, the graphics have been cleaned up, with the band members looking sharper than ever. This was one of the universal complaints that I found from the first game, even though most people focus on the interface itself.
On the flip side, there havent been many changes made overall. This can be both good and bad, and it just depends on the way you look at it.
While Rock Band did a fantastic job the first time through, some people may be disappointed in the fact that nothing has drastically changedor at least we havent heard of anything changed from Harmonix.